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Conversely, IFN-α/β can stimulate Th2 cells, Treg cells, and M2 macrophages to secrete IL-4, IL-10, and PD-1, which suppress the expression of pro-inflammatory factors and adhesion molecules such as TNF-α, IL-1β, and IL-8 and in turn downregulates MHC I expression to suppress CTL activation, thereby achieving immune control (89–93)

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Germline fumarate hydratase mutations and evidence for a founder mutation underlying multiple cutaneous and uterine leiomyomata